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Here you will find links to medical articles on the net that deal specifically with problems associated with paroxetine discontinuation. The bibliography below has been obtained by searching through the medline database.

FDA Advisory Sept 2005(pdf)
Antidepressant Use in Children, Adolescents, and Adults (FDA)
Current information on the use of antidepressants in pediatric patients

FDA PUBLIC HEALTH ADVISORY
FDA Statement Regarding the Anti-Depressant Paxil for Pediatric Population
FDA's new label information for Paxil (2002)
Antidepressant discontinuation reactions
Persistent adverse neurological effects following SSRI discontinuation .
Reports of SSRI withdrawal reaction
SSRI Withdrawal Syndrome
SSRI Discontinuation Syndrome
SSRI Discontinuation Syndrome
Antidepressant Discontinuation Syndromes
Canadian Adverse Reaction Newsletter Volume 13, Number 2, April 2003
SSRI Discontinuation Syndrome

Montgomery SA, Kennedy SH, Burrows GD, Lejoyeux M, Hindmarch I.
Absence of discontinuation symptoms with agomelatine and occurrence of
discontinuation symptoms with paroxetine: a randomized, double-blind,
placebo-controlled discontinuation study.
Int Clin Psychopharmacol. 2004 Sep;19(5):271-80.
PMID: 15289700 [PubMed - indexed for MEDLINE]

Haddad PM, Dursun SM.
Re: Depression, stroke diagnosis, and SSRI discontinuation syndrome.
Can J Psychiatry. 2004 May;49(5):343-4; author reply 345-6. No abstract
available.
PMID: 15198473 [PubMed - indexed for MEDLINE]

Jessel N, Stiskal JA.
Neonatal encephalopathy after antidepressant exposure during pregnancy. Herbst
F, Gortner L. Paroxetine withdrawal syndrome as differential diagnosis of acute
neonatal encephalophathy? Z Geburtsh Neonatol 2003; 207: 232-234.
Z Geburtshilfe Neonatol. 2004 Apr;208(2):75-6; author reply 76. English,
German. No abstract available.
PMID: 15112141 [PubMed - indexed for MEDLINE]

Mazzatenta C, Peonia G, Martini P.
Pruritus induced by interruption of paroxetine therapy.
Br J Dermatol. 2004 Apr;150(4):787. No abstract available.
PMID: 15099390 [PubMed - indexed for MEDLINE]

Hayakawa Y, Sekine A, Shimizu T.
Delirium induced by abrupt discontinuation of paroxetine.
J Neuropsychiatry Clin Neurosci. 2004 Winter;16(1):119-20. No abstract
available.
PMID: 14990771 [PubMed - indexed for MEDLINE]

Herbst F, Gortner L.
[Paroxetine withdrawal syndrome as differential diagnosis of acute neonatal
encephalopathy?]
Z Geburtshilfe Neonatol. 2003 Nov-Dec;207(6):232-4. German.
PMID: 14689334 [PubMed - indexed for MEDLINE]

Antai-Otong D.
Antidepressant discontinuation syndrome.
Perspect Psychiatr Care. 2003 Jul-Sep;39(3):127-8. No abstract available.
PMID: 14606234 [PubMed - indexed for MEDLINE]

Kaufman MJ, Henry ME, Frederick B, Hennen J, Villafuerte RA, Stoddard EP,
Schmidt ME, Cohen BM, Renshaw PF.
Selective serotonin reuptake inhibitor discontinuation syndrome is associated
with a rostral anterior cingulate choline metabolite decrease: a proton magnetic
resonance spectroscopic imaging study.
Biol Psychiatry. 2003 Sep 1;54(5):534-9.
PMID: 12946882 [PubMed - indexed for MEDLINE]

[No authors listed]
Paroxetine withdrawal syndrome.
Prescrire Int. 2003 Aug;12(66):141. No abstract available.
PMID: 12908493 [PubMed - indexed for MEDLINE]

Ramasubbu R.
Minor strokes related to paroxetine discontinuation in an elderly subject:
emergent adverse events.
Can J Psychiatry. 2003 May;48(4):281-2. No abstract available.
PMID: 12776398 [PubMed - indexed for MEDLINE]

Ali S, Milev R.
Switch to mania upon discontinuation of antidepressants in patients with mood
disorders: a review of the literature.
Can J Psychiatry. 2003 May;48(4):258-64. Review.
PMID: 12776393 [PubMed - indexed for MEDLINE]

Salvia-Roiges MD, Garcia L, Gonce-Mellgren A, Esque-Ruiz MT, Figueras-Aloy
J, Carbonell-Estrany X.
[Neonatal convulsions and subarachnoid hemorrhage after in utero exposure to
paroxetine]
Rev Neurol. 2003 Apr 16-30;36(8):724-6. Spanish.
PMID: 12717649 [PubMed - indexed for MEDLINE]

Green B.
Focus on paroxetine.
Curr Med Res Opin. 2003;19(1):13-21. Review.
PMID: 12661775 [PubMed - indexed for MEDLINE]

Finfgeld DL.
Selective serotonin reuptake inhibitor. Discontinuation syndrome.
J Psychosoc Nurs Ment Health Serv. 2002 Dec;40(12):14-8.
PMID: 12491870 [PubMed - indexed for MEDLINE]

Judge R, Parry MG, Quail D, Jacobson JG.
Discontinuation symptoms: comparison of brief interruption in fluoxetine and
paroxetine treatment.
Int Clin Psychopharmacol. 2002 Sep;17(5):217-25.
PMID: 12177584 [PubMed - indexed for MEDLINE]

Trenque T, Piednoir D, Frances C, Millart H, Germain ML.
Reports of withdrawal syndrome with the use of SSRIs: a case/non-case study in
the French Pharmacovigilance database.
Pharmacoepidemiol Drug Saf. 2002 Jun;11(4):281-3.
PMID: 12138595 [PubMed - indexed for MEDLINE]

Shoenberger D.
Discontinuing paroxetine: a personal account.
Psychother Psychosom. 2002 Jul-Aug;71(4):237-8. No abstract available.
PMID: 12097790 [PubMed - indexed for MEDLINE]

Terao T.
Palinopsia and paroxetine withdrawal.
J Clin Psychiatry. 2002 Apr;63(4):368. No abstract available.
PMID: 12000213 [PubMed - indexed for MEDLINE]

Bogetto F, Bellino S, Revello RB, Patria L.
Discontinuation syndrome in dysthymic patients treated with selective serotonin
reuptake inhibitors: a clinical investigation.
CNS Drugs. 2002;16(4):273-83.
PMID: 11945110 [PubMed - indexed for MEDLINE]

Tonks A.
Withdrawal from paroxetine can be severe, warns FDA.
BMJ. 2002 Feb 2;324(7332):260. No abstract available.
PMID: 11823353 [PubMed - indexed for MEDLINE]

Isbister GK, Dawson A, Whyte IM, Prior FH, Clancy C, Smith AJ.
Neonatal paroxetine withdrawal syndrome or actually serotonin syndrome?
Arch Dis Child Fetal Neonatal Ed. 2001 Sep;85(2):F147-8. No abstract available.
PMID: 11561552 [PubMed - indexed for MEDLINE]

Haddad PM, Devarajan S, Dursun SM.
Antidepressant discontinuation (withdrawal) symptoms presenting as 'stroke'.
J Psychopharmacol. 2001 Jun;15(2):139-41.
PMID: 11448088 [PubMed - indexed for MEDLINE]

Einarson A, Selby P, Koren G.
Discontinuing antidepressants and benzodiazepines upon becoming pregnant.
Beware of the risks of abrupt discontinuation.
Can Fam Physician. 2001 Mar;47:489-90.
PMID: 11281079 [PubMed - indexed for MEDLINE]

Stiskal JA, Kulin N, Koren G, Ho T, Ito S.
Neonatal paroxetine withdrawal syndrome.
Arch Dis Child Fetal Neonatal Ed. 2001 Mar;84(2):F134-5.
PMID: 11207233 [PubMed - indexed for MEDLINE]

Haddad PM, Qureshi M.
Misdiagnosis of antidepressant discontinuation symptoms.
Acta Psychiatr Scand. 2000 Dec;102(6):466-7; discussion 467-8.
PMID: 11142438 [PubMed - indexed for MEDLINE]

Hindmarch I, Kimber S, Cockle SM.
Abrupt and brief discontinuation of antidepressant treatment: effects on
cognitive function and psychomotor performance.
Int Clin Psychopharmacol. 2000 Nov;15(6):305-18.
PMID: 11110006 [PubMed - indexed for MEDLINE]

Diler RS, Tamam L, Avci A.
Withdrawal symptoms associated with paroxetine discontinuation in a
nine-year-old boy.
J Clin Psychopharmacol. 2000 Oct;20(5):586-7. No abstract available.
PMID: 11001250 [PubMed - indexed for MEDLINE]

Kirsch MA, Louie AK.
Paroxetine and irritable bowel syndrome.
Am J Psychiatry. 2000 Sep;157(9):1523-4. No abstract available.
PMID: 10964877 [PubMed - indexed for MEDLINE]

Black K, Shea C, Dursun S, Kutcher S.
Selective serotonin reuptake inhibitor discontinuation syndrome: proposed
diagnostic criteria.
J Psychiatry Neurosci. 2000 May;25(3):255-61. Review.
PMID: 10863885 [PubMed - indexed for MEDLINE]

Belloeuf L, Le Jeunne C, Hugues FC.
[Paroxetine withdrawal syndrome]
Ann Med Interne (Paris). 2000 Apr;151 Suppl A:A52-3. French.
PMID: 10855379 [PubMed - indexed for MEDLINE]

Michelson D, Fava M, Amsterdam J, Apter J, Londborg P, Tamura R, Tepner RG.
Interruption of selective serotonin reuptake inhibitor treatment. Double-blind,
placebo-controlled trial.
Br J Psychiatry. 2000 Apr;176:363-8.
PMID: 10827885 [PubMed - indexed for MEDLINE]

Fagan M.
[Withdrawal syndrome after the use of serotonin reuptake inhibitors]
Tidsskr Nor Laegeforen. 2000 Mar 20;120(8):913-4. Norwegian.
PMID: 10795494 [PubMed - indexed for MEDLINE]

Nuss S, Kincaid CR.
Serotonin discontinuation syndrome: does it really exist?
W V Med J. 2000 Mar-Apr;96(2):405-7.
PMID: 10771628 [PubMed - indexed for MEDLINE]

Strickland GM, Hough DW.
Unilateral facial numbness and visual blurring associated with paroxetine
discontinuation.
J Clin Psychopharmacol. 2000 Apr;20(2):271-2. No abstract available.
PMID: 10770473 [PubMed - indexed for MEDLINE]

Peeters FP, Zandbergen J.
[Severe withdrawal symptoms with fever during paroxetine tapering off]
Ned Tijdschr Geneeskd. 1999 Jul 3;143(27):1429-31. Dutch.
PMID: 10422558 [PubMed - indexed for MEDLINE]

Gram LF.
[Withdrawal symptoms in connection with the use of selective serotonin reuptake
inhibitors (SSRI)]
Ugeskr Laeger. 1998 Dec 7;160(50):7291-3. Danish. No abstract available.
PMID: 9859737 [PubMed - indexed for MEDLINE]

Thompson C.
Discontinuation of antidepressant therapy: emerging complications and their
relevance.
J Clin Psychiatry. 1998 Oct;59(10):541-8. No abstract available.
PMID: 9818638 [PubMed - indexed for MEDLINE]

Pollock BG.
Discontinuation symptoms and SSRIs.
J Clin Psychiatry. 1998 Oct;59(10):535-7. No abstract available.
PMID: 9818635 [PubMed - indexed for MEDLINE]

Wincor MZ.
Withdrawal syndrome associated with abrupt discontinuation of SSRIs.
J Am Pharm Assoc (Wash). 1998 Jul-Aug;38(4):500-1. No abstract available.
PMID: 9707961 [PubMed - indexed for MEDLINE]

Rosenbaum JF, Fava M, Hoog SL, Ascroft RC, Krebs WB.

Selective serotonin reuptake inhibitor discontinuation syndrome: a randomized
clinical trial.
Biol Psychiatry. 1998 Jul 15;44(2):77-87.
PMID: 9646889 [PubMed - indexed for MEDLINE]

Bryois C, Rubin C, Zbinden JD, Baumann P.
[Withdrawal syndrome caused by selective serotonin reuptake inhibitors: apropos
of a case]
Schweiz Rundsch Med Prax. 1998 Mar 4;87(10):345-8. Review. French.
PMID: 9545842 [PubMed - indexed for MEDLINE]

Stahl MM, Lindquist M, Pettersson M, Edwards IR, Sanderson JH, Taylor NF,
Fletcher AP, Schou JS.

Withdrawal reactions with selective serotonin re-uptake inhibitors as reported
to the WHO system.
Eur J Clin Pharmacol. 1997;53(3-4):163-9.
PMID: 9476026 [PubMed - indexed for MEDLINE]

Zajecka J, Tracy KA, Mitchell S.
Discontinuation symptoms after treatment with serotonin reuptake inhibitors: a
literature review.
J Clin Psychiatry. 1997 Jul;58(7):291-7. Review.
PMID: 9269249 [PubMed - indexed for MEDLINE]

Walker-Kinnear M, McNaughton S.
Paroxetine discontinuation syndrome in association with sertindole therapy.
Br J Psychiatry. 1997 Apr;170:389. No abstract available.
PMID: 9246265 [PubMed - indexed for MEDLINE]

Young AH, Currie A, Ashton CH.
Antidepressant withdrawal syndrome.
Br J Psychiatry. 1997 Mar;170:288. No abstract available.
PMID: 9229040 [PubMed - indexed for MEDLINE]

Landry P, Roy L.
Withdrawal hypomania associated with paroxetine.
J Clin Psychopharmacol. 1997 Feb;17(1):60-1. No abstract available.
PMID: 9004064 [PubMed - indexed for MEDLINE]

Rosenbaum JF, Zajecka J.
Clinical management of antidepressant discontinuation.
J Clin Psychiatry. 1997;58 Suppl 7:37-40. Review.
PMID: 9219493 [PubMed - indexed for MEDLINE]

Haddad P.
Newer antidepressants and the discontinuation syndrome.
J Clin Psychiatry. 1997;58 Suppl 7:17-21; discussion 22. Review.
PMID: 9219489 [PubMed - indexed for MEDLINE]

Lejoyeux M, Ades J.
Antidepressant discontinuation: a review of the literature.
J Clin Psychiatry. 1997;58 Suppl 7:11-5; discussion 16. Review.
PMID: 9219488 [PubMed - indexed for MEDLINE]

Arya DK.
Withdrawal after discontinuation of paroxetine.
Aust N Z J Psychiatry. 1996 Oct;30(5):702. No abstract available.
PMID: 8902183 [PubMed - indexed for MEDLINE]

Coupland NJ, Bell CJ, Potokar JP.
Serotonin reuptake inhibitor withdrawal.
J Clin Psychopharmacol. 1996 Oct;16(5):356-62.
PMID: 8889907 [PubMed - indexed for MEDLINE]

Pacheco L, Malo P, Aragues E, Etxebeste M.
More cases of paroxetine withdrawal syndrome.
Br J Psychiatry. 1996 Sep;169(3):384. No abstract available.
PMID: 8879736 [PubMed - indexed for MEDLINE]

Mareth TR, Brown TM.
SSRI withdrawal.
J Clin Psychiatry. 1996 Jul;57(7):310. No abstract available.
PMID: 8666577 [PubMed - indexed for MEDLINE]

Lazowick AL, Levin GM.
Potential withdrawal syndrome associated with SSRI discontinuation.
Ann Pharmacother. 1995 Dec;29(12):1284-85. No abstract available.
PMID: 8672834 [PubMed - indexed for MEDLINE]

Dominguez RA, Goodnick PJ.
Adverse events after the abrupt discontinuation of paroxetine.
Pharmacotherapy. 1995 Nov-Dec;15(6):778-80.
PMID: 8602387 [PubMed - indexed for MEDLINE]

Fava GA, Grandi S.
Withdrawal syndromes after paroxetine and sertraline discontinuation.
J Clin Psychopharmacol. 1995 Oct;15(5):374-5. No abstract available.
PMID: 8830071 [PubMed - indexed for MEDLINE]

Rafieian-Kopaei M, Gray AM, Spencer PS, Sewell RD.
Contrasting actions of acute or chronic paroxetine and fluvoxamine on morphine
withdrawal-induced place conditioning.
Eur J Pharmacol. 1995 Mar 6;275(2):185-9.
PMID: 7796854 [PubMed - indexed for MEDLINE]

Pyke RE.
Paroxetine withdrawal syndrome.
Am J Psychiatry. 1995 Jan;152(1):149-50. No abstract available.
PMID: 7802108 [PubMed - indexed for MEDLINE]

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