For anyone who missed the previous Resident Evil films, Jovovich plays Alice, one of the few people left on Earth not infected with the Umbrella Corporation's T-Virus, which turns its victims into zombies. Genetically altered to be super strong and agile by the sinister Dr. Isaacs (Iain Glen), Alice has found a refuge of sorts in the Nevada wasteland, where she ultimately meets a ragged band of survivors, led by her Resident Evil: Apocalypse friend Carlos Oliveira (Oded Fehr) and Claire Redfield (Larter). After many skirmishes with zombies and T-Virus infected crows, they decide to set out for distant Alaska, supposedly beyond the reach of the T-Virus. But first they'll have to stop to refuel in Las Vegas, where they'll run up against zombies and Isaacs, who needs Alice's blood for his evil plan of transforming the zombies into his slaves.

Directed by Mulcahy (Highlander) with all the enthusiasm of a convicted felon reporting for court-ordered community service, Resident Evil: Extinction offers up more of the same, i.e., scantily clad babes kicking zombie butt, in a ho-hum film that can't even muster up a decent cheap thrill or two. Mulcahy and producer/screenwriter Paul Anderson crib shamelessly and ineptly from such films as The Road Warrior (1982), 28 Days Later (2003), Pitch Black (2000) and George Romero's Day of the Dead (1985), among others, in this vehicle for Jovovich, the reigning queen of the B's—as in bores.